Kinetics of Decomposition of Irbesartan in Aqueous Solutions Determined by High Performance Liquid Chromatography

Abstract

The kinetics of breakdown of irbesartan in aqueous solutions at elevated temperatures has been investigated by a high performance liquid chromatography method. The reaction is found to follow first-order kinetics and the rate constant for the degradation at 25 _C is estimated by extrapolation. The decomposition of irbesartan is shown to be hydroxide ion catalysed and the effects of ionic strength and buffer concentrations to such rate studies are discussed.