Abstract:
Objective: To investigate the antisecrectory activities of the methanol extract, chloroform fraction and methanol fraction of Picralima nitida seeds.
Methods: The methanol extract of Picralima nitida seeds was fractionated into chlorofoam fraction and methanol fraction. They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.
Results: Oral administration of the methanol extract, chlorofoam fraction and methanol fraction at 1000 mg/kg reduced gastric ulcer by 56.4%, 40.0% and 56.3, respectively; and the fractions of the extract significantly (P<0.05) reduced gastric emptying time when compared to the control. Gastric acidity was significantly decreased when compared with saline group, 40.25mEq/L in methanol extract, 50.0 mEq/L in chlorofoam fraction, 51.25mEq/L in methanol fraction but had no significant effect on the gastric secretion volume.
Conclusion: These findings showed that methanol extract, chlorofoam fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecertory properties.
