dc.contributor.author |
Ukwe, Chinwe V.
|
|
dc.contributor.author |
Ekwunife, Obinna I.
|
|
dc.contributor.author |
Ekpueke, Ebele A.
|
|
dc.contributor.author |
Ubaka, Chukwuemeka M.
|
|
dc.date.accessioned |
2018-06-06T10:22:11Z |
|
dc.date.available |
2018-06-06T10:22:11Z |
|
dc.date.issued |
2010 |
|
dc.identifier.citation |
Ukwe, C.V., Ekwunife, O.I., Epueke, E.A.& Ubaka C.M.(2010) Antimalarial Activity of Ageratum conyzoides in Combination with Chloroquine and Artesunate.Asian Pacific Journal of Tropical Medicine 943-947 |
en_US |
dc.identifier.uri |
http://repository.unn.edu.ng:8080/xmlui/handle/123456789/7042 |
|
dc.description.abstract |
Objective: To determine the suppressive and curative activity of aqueous leaf extract of Ageratum conyzoides ( A. conyzoides) in combination with chloroquine and artesunate, respectively against Plasmodium berghei infection in mice.
Methods: Using malaria (Plasmodium berghei) infected albino mice of both sexes, aqueous extracts of A. conyzoides in combination with chloroquine and artesunate were tested for antimalarial activity, respectively. Four-day suppressive test and Rane's curative test were carried out.
Results: Suppressive tests showed significant dose dependent reduction in parasitemia level produced by the extract-chloroquine and extract-artesunate combinations. Suppressive activities of both extract-drug combinations were greater than the individual drugs alone. Extract-chloroquine (100:5) produced the highest suppressive effect (98% suppression). Curative tests showed absolute survival in two extract-drug combinations. Two extract-drug combinations produced higher curative effects than the individual drugs alone. The highest dose combinatons of extract-chloroquine (100:5) and extract-artesunate (100:5) produced absolute parasitemia clearance (cure) in the infected mice.
Conclusion: The study indicated that aqueous extract of A. conyzoides had the ability to potentiate the antimalarial activity of chloroquine and artesunate against induced plasmodiasis in mice. It contributes a lot in the malaria endemic and poverty stricken tropics. |
en_US |
dc.language.iso |
en |
en_US |
dc.subject |
Ageratum Conyzoides |
en_US |
dc.subject |
Antimalarial Activity |
en_US |
dc.subject |
Artesunate |
en_US |
dc.subject |
Plasmodium Berghei Infection |
en_US |
dc.subject |
Chloroquine |
en_US |
dc.subject |
Ukwe, C.V. et al |
en_US |
dc.title |
Antimalarial Activity of Ageratum conyzoides in Combination with Chloroquine and Artesunate |
en_US |
dc.type |
Recording, oral |
en_US |
dc.type |
Software |
en_US |
dc.type |
Technical Report |
en_US |