Abstract:
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, and neuropathy and causing neurological disorders due to perturbation in utilization ofglucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Garcinia kola seeds, has beenclaimed to possess antidiabetic properties by many investigators. The present study was undertaken to screen the hypoglycemic activityof ethanol extract, the fraction and compounds of G. kola seeds. The results showed thatthe extract, fraction, compounds and the reference drug (glibenclamide) showed different levels of antidiabetic effect. However, GB2 gave the best antidiabetic effect which is an improvement from that of the extract. The effect of GB2 was similar to glibenclamide.
