Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2-Naphthol

Abstract

The usefulness of non-steroidal anti-inflammatory agents in the management of rheumatoid & diseases cannot be over- emphasized. As this disease is characterised by chronic inflammation, it is usual to test compounds foranti-inflammatory activity in animals and then hope that the active ones should be clinically useful as anti-rheumatic drugs. From the literature, non-steroidal anti-inflammatory agents have covered a wide range of chemical structures aryl acetic, aryl-propionic, arylbutyric and anthranilic acid derivatives, Other compounds including the benzothiazines are also known to be potent agents. This work involved the synthesis of some aminomethyl derivatives of 2-naphthol and screenin$ them as potential anti-inflammatory agents. These derivatives from the point of view of thsir electronic and stereochemical characteristics are considered to be similar to the known bis(2-hydroxynaphthy1)- methane derivatives, earlier reported to have pronounced anti-inflammatory activity, The physicochemical properties of these compounds were .also determined in an effort to correlate observed biological activity and chemical structure.