http://repository.unn.edu.ng/handle/123456789/481 Wed, 02 Sep 2026 19:06:15 GMT 2026-09-02T19:06:15Z http://repository.unn.edu.ng/handle/123456789/7162 Spectrophotometric Determination of Chlorpropamide in Bulk and Dosage Form by Complexation with Chloranilic Acid Mbah, C.J.; Okorie, H.N. A spectrophotometric study of chlorpropamide is described. The method is based on the charge-transfer complexation between chlorpropamide (the n-electron donor) with chloranilic acid (the π-acceptor) to form a violet coloured complex having absorption maxima at 530 nm. Beer’s law is obeyed for up to 5-25 µg/ml of chlorpropamide. Results of the analysis of this method were validated statistically by recovery studies. The proposed method is simple, accurate and precise for the quantitative determination of chlorpropamide in bulk and tablet formulations. Sat, 01 Jan 2011 00:00:00 GMT http://repository.unn.edu.ng/handle/123456789/7162 2011-01-01T00:00:00Z http://repository.unn.edu.ng/handle/123456789/7160 Formulation Development of Theophylline in Coated Polymeric Pellets for Controlled Oral Drug Delivery Obitte, Nicholas, C.; Okorie, Abali, Sunday This work is aimed at producing theophylline pellets for controlled oral drug delivery. Eight batches of theophylline pellets were prepared containing varying combinations (2.5 – 10% w/w) of sodium carboxymethyl cellulose, ethylcellulose and eudragit L-100 55. The flow properties of the pellets were determined and batches II and IV, which had the best flow were coated up to 30 – 60% using eudragit L- 100. Sequential dissolution studies were carried out on the coated pellets in simulated gastric fluid (SGF), pH 1.2; simulated intestinal fluid (SIF), pH 6.8 and stimulated colonic fluid (SCF), pH 7.4. The dissolution data were subjected to kinetic treatment. The 30% coated pellets released uniform amounts of theophylline in the three media unlike the other batches. Though the coated pellets had the same super case-II transport mechanism of drug release, their release kinetics were different. The 30% coated batch-II pellets had the best controlled oral delivery of theophylline. Thu, 01 Jan 2015 00:00:00 GMT http://repository.unn.edu.ng/handle/123456789/7160 2015-01-01T00:00:00Z http://repository.unn.edu.ng/handle/123456789/7159 Kinetics of Decomposition of Irbesartan in Aqueous Solutions Determined by High Performance Liquid Chromatography Mbah, C.J. The kinetics of breakdown of irbesartan in aqueous solutions at elevated temperatures has been investigated by a high performance liquid chromatography method. The reaction is found to follow first-order kinetics and the rate constant for the degradation at 25 _C is estimated by extrapolation. The decomposition of irbesartan is shown to be hydroxide ion catalysed and the effects of ionic strength and buffer concentrations to such rate studies are discussed. Thu, 01 Jan 2004 00:00:00 GMT http://repository.unn.edu.ng/handle/123456789/7159 2004-01-01T00:00:00Z http://repository.unn.edu.ng/handle/123456789/7145 Physical and Mechanical Effects of Starch-Gelatin Binary Binder Mixtures on Sodium Salicylate Tablets Agubata, Chukwuma O.; Onunkwo, Godswill C.; Ugwu, Calister, E.; Chime, Salome, A. Starch- gelatin binary binder mixtures were applied in the formulation of sodium salicylate tablets. Locally developed cassava starch (tapioca starch) was used as a co-binder with gelatin. Wet granulation method was used to formulate different batches of sodium salicylate tablets with varying binder concentrations (1-5%w/w) and starch gelatin binder ratios (25:75, 50:50, 75:25 and 0:100). The sodium salicylate granules were evaluated for flow properties, friability, moisture uptake while the tablets were assessed for crushing strength, friability and crushing strength-friability ratio (CSFR). Formulations prepared with gelatin, had lower granule friability than those produced with cassava starch gelatin binder mix. Flow properties did not follow any definite pattern ,whereas moisture uptake studies showed that gelatin batches absorbed more moisture than cassava starch-gelatin batches. As the gelatin content decreased, the tablet crushing strength and CSFR decreased while the friability increased. The mechanical strength and moisture uptake of the gelatin based granules or tablets reduced with the incorporation of cassava starch Sun, 01 Jan 2012 00:00:00 GMT http://repository.unn.edu.ng/handle/123456789/7145 2012-01-01T00:00:00Z